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. 2022 Jul 27;23(15):8284. doi: 10.3390/ijms23158284

Figure 1.

Figure 1

Cisplatin-induced body weight loss and mortality rate. Basal body weight on day 0 (A) and percentage change in body weight, relative to basal (day 0) values, on days 1–3 after cisplatin (Cp) or saline injections (B) were measured in male mice, homozygous (homo) and heterozygous (het) knockout for GPER1 gene, and wild-type (WT) littermates. The number of animals (WT, het, and homo) that survived or died in response to Cp or saline injections (C) was recorded during the first 3 days after the injections. Mice were injected with Cp (20 mg/kg) or saline on day 0. Data are presented as mean ± SEM (n = 9–17 mice/group). Statistical comparisons were performed by two-way ANOVA (A) or repeated measures two-way ANOVA (B) with Sidak’s post hoc test for multiple comparisons. p values for ANOVA and post hoc test results are displayed on the figures. For the three-way ANOVA, only p < 0.05 is displayed for clarity. Cp, cisplatin; Het: heterozygous knockout for GPER1 gene; Homo, homozygous knockout for GPER1 gene; Sal, saline; WT, wild-type.