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. 2022 Jul 27;23(15):8284. doi: 10.3390/ijms23158284

Figure 2.

Figure 2

Cisplatin-induced rise in serum levels of kidney injury markers. Serum levels of creatinine (SCr, (A)), urea (B), and neutrophil gelatinase-associated lipocalin (NGAL, (C)) on day 3 after cisplatin (Cp, 20 mg/kg) or saline injections were measured in male, mice homozygous (homo) and heterozygous (het) knockout for GPER1 gene, and wild-type (WT) littermates. Data are presented as mean ± SEM (n = 4–13 mice/group). Statistical comparisons were performed by two-way ANOVA with Sidak’s post hoc test for multiple comparisons (A–C). p values for ANOVA and post hoc test results are displayed on the figures. Cp, cisplatin; Het: heterozygous knockout for GPER1 gene; Homo, homozygous knockout for GPER1 gene; Sal, saline; SCr, serum creatinine; WT, wild-type.