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. 2022 Jul 27;23(15):8284. doi: 10.3390/ijms23158284

Figure 5.

Figure 5

GPER1 deletion blunts cisplatin-induced rise in kidney heme oxygenase-1. Representative images for Western blots on total kidney lysates for heme oxygenase-1 (HO-1, (A)) measured on day 3 after cisplatin (Cp, 20 mg/kg) or saline injections in male mice, homozygous (homo) and heterozygous (het) knockout for GPER1 gene, and wild-type (WT) littermates. Densitometric values (AU, arbitrary units) for kidney levels of HO-1 (B) were normalized to the Ponceau S staining. Data are presented as mean ± SEM (n = 8–13 mice/group). Statistical comparisons were performed by two-way ANOVA with Sidak’s post hoc test for multiple comparisons (B). p values for ANOVA and post hoc test results are displayed on the figures. AU, arbitrary units; Cp, cisplatin; Het: heterozygous knockout for GPER1 gene; HO-1, heme oxygenase; Homo, homozygous knockout for GPER1 gene; Sal, saline; WT, wild-type.