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. 2022 Jul 27;23(15):8313. doi: 10.3390/ijms23158313

Figure 6.

Figure 6

Effects of beta-blocker on the beating variability and arrhythmic events in BrS-hiPSC-CMs. Spontaneous calcium transients were recorded in regularly beating hiPSC-CMs from the BrS patient and the isogenic control(isogenic) in the absence (baseline) and presence of 30 nM, 300 nM and 3000 nM bisoprolol (Biso). The beating variability (standard deviation (SD) of cell beating intervals) and the occurrence of arrhythmic events (irregular or triggered beats or EAD-like events) were compared between with and without drug application. (A) Representative trace of BrS (at baseline) and after the administration of different concentrations of bisoprolol. (B) Mean values of standard deviation (SD) of cell beating intervals. (C) Percentage of cells showing arrhythmic events. * p < 0.05 versus isogenic according to Fisher’s exact test (C) or versus baseline according to t-test (B).