Table 1.
The above table shows the genes playing roles in specific biological processes from the network generated between COL5A1 and TIMP1 gene interactions, which has a significant role in corneal wound healing.
| Gene Ontology ID | Biological Process | Genes Involved | False Discovery Ratio |
|---|---|---|---|
| GO:0032964 | Collagen biosynthetic process | COL5A1, COL1A1 | 0.0028 |
| GO:1905048 | Regulation of metallopeptidase activity | TIMP1, TIMP2, STAT3 | 0.00013 |
| GO:0070102 | Interleukin-6-mediated signaling pathway | IL-6, STAT3, | 0.0061 |
| GO:0030199 | Collagen fibril organization | COL5A1, COL1A1, COL3A1, LUM | 3.5 × 10−5 |
| GO:0035633 | Maintenance of blood-brain barrier | VEGF, IL-6 | 0.0171 |
| GO:0048661 | Positive regulation of smooth muscle cell proliferation | MMP9, IL-6, IL-13, IL-10 | 0.00021 |
| GO:0042060 | Wound healing | COL5A1, COL1A1, COL3A1, TIMP1, HIF1A, VEGFA, IL-6, TGFB-1 | 3.4 × 10−6 |
| GO:0060485 | Mesenchyme development | ACTA2/SMA, TGFB1, HIF1A | 0.0299 |