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. 2022 Jul 28;13:936606. doi: 10.3389/fimmu.2022.936606

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Copyright © 2022 Liu, Lu, Liu, Ning, Li, Chen, Ge, Guo, Zheng, Wei and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Integrative construction of the MAGDS. (A) Protein-Protein Interaction (PPI) network of DEMAGs. (B) The 21 red nodes we highlighted in the network were hub genes identified by cytoHubba-degree algorithm. (C) Out of bag (OOB) error rate reached a minimum when the number of trees was equal to 35. (D) Relative importance of 41 up-regulated DEMAGs calculated in random forest. (E) Venn diagram of the intersection of important gene variables obtained from PPI analysis and random forest pre-screening. (F) The optimal lambda was determined when the partial likelihood deviance reached the minimum value. (G) LASSO coefficient profiles of the candidate genes for MAGDS construction.