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. 2022 Aug 4;23(15):8656. doi: 10.3390/ijms23158656

Figure 1.

Figure 1

CD95 stimulation and potential links to inflammation activation. Three molecular complexes can occur with CD95 involvement to induce chronic inflammation (blue circle), apoptosis (pink circle), or necrosis (green circle). Apoptotic and necroptotic complexes control each other and the inflammatory complex (black lines). CD95 (FAS) promotes DC maturation and differentiation of Th17 and induction of the secretion of pro-inflammatory cytokines (IL-1β, TNF-α) and CXC or CC chemokines. The CD95-mediated apoptotic and non-apoptotic signaling pathways share many factors, such as the apoptotic factors FADD and caspase-8. Interaction of CD95 L with CD95 favors the recruitment of FADD to the death domain of CD95. Abbreviations: Th, T helper; DCs, dendritic cells; IL, Interleukin; TNF, Tumoral necrosis factor; CD95L, CD95 Ligand; MMP, Matrix metalloproteinase; PSGL-1, P-selectin glycoprotein ligand-1; FADD, Fas-associated death domain; Casp8, Caspase-8.