Figure 5.
In vivo imaging of the rd LRP. (a,b) The amide proton CEST amplitudes of glioma cells that did not express rd LRP (a) and expressed rd LRP (b) in mouse brain. (c) Comparison of the T2 relaxation time of the two groups. The results showed no significant difference, and there was edema in the tumor area. (d,e) T2-weighted imaging corresponding to (a,b) respectively. (f,g) Overlay of the amide proton CEST contrast (obtained using a frequency selective saturation pulse (a,b)) on the (d,e) image. (h) Comparison of CEST amplitudes of amide proton. CEST signal increased significantly in rd LRP group. Reproduced with permission from Ref. [41], 2020.