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Criteria for surrogate IHC subtyping according to [16].
| Surrogate Subtype | Subgroup | ER | PR | HER2 | Ki-67 (%) | |
|---|---|---|---|---|---|---|
| Luminal A-like | + | +/− | − | and | Low (<20%) | |
| Luminal B-like | HER2 negative | + | +/− | − | and | High (≥20%) |
| HER2 positive | + | +/− | + | Any value | ||
| HER2 positive (non-luminal) | − | − | + | Any value | ||
| Triple negative | − | − | − | Any value |
ER: estrogen receptor; HER2: human epidermal growth factor receptor 2; IHC: immunohistochemistry; Ki-67: proliferation marker; PR: progesterone receptor.
