Figure 5.

Study design. All animals were fed a hypercholesterolemic diet for the first 10 days of the study. From this day onwards, the animals were randomly divided into four groups to receive 30 days of (I) hypercholesterolemic diet alone (n = 9), (II) hypercholesterolemic diet with 40 mg rosuvastatin daily (n = 7), (III) normocholesterolemic diet alone (n = 8), (IV) normocholesterolemic diet with 40 mg rosuvastatin daily (n = 8). Samples were collected at indicated timepoints. HDL: high-density lipoprotein; CEC: cholesterol efflux capacity; AOI: antioxidant index; WB: Western blot. * High-fat and normal diet refer to hypercholesterolemic and normocholesterolemic diet, respectively.