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. 2022 Aug 1;23(15):8538. doi: 10.3390/ijms23158538

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of CRH-R1 antagonist on diarrhea occurrence, microscopic findings, and mRNA expressions in the ileum. Effects of the CRH-R1 antagonist on diarrhea occurrence (A), villus/crypt ratio (B), number of eosinophils (C), and mast cells (D) in the ileal mucosa of WAS + OVA-treated mice. Effects of the CRH-R1 antagonist on ileal mRNA expressions of eotaxin-1 (E) and tpsb2 (F) in WAS + OVA-treated mice. * p < 0.05, ** p < 0.01. CRH-R1, corticotropin-releasing hormone type 1 receptor; OVA, ovalbumin; tpsb2, tryptase beta 2; WAS, water avoidance stress.