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Schematic abstract of the information presented in this review. Briefly, the Trp metabolism is important in several processes connected with depression, particularly neuroinflammation, stress response, gut microbiota dysregulation, and brain-derived neurotrophic factor activity. Illustration created with BioRender [8]. TPH2: tryptophan hydroxylase 2; 5-HT1A: serotonin 1A receptor; IDO: indoleamine 2-3-dioxygenase 1; TDO: tryptophan 2,3-dioxygenase; SERT: serotonin transporter.
