Table 1.
List of the 97 papers retrieved with our search. Authors have been listed in alphabetical order. Journal names are abbreviated according to MedLine nomenclature.
| Author | Year | Journal | Article Title | Ref. |
|---|---|---|---|---|
| Abaffy et al. | 2013 | Metabolomics | Comparative analysis of volatile metabolomics signals from melanoma and benign skin: a pilot study | [19] |
| Abaffy et al. | 2011 | J Cancer Sci Ther. | A case report—Volatile metabolomic signature of malignant melanoma using matching skin as a control | [20] |
| Abaffy et al. | 2010 | PLoS ONE | Differential Volatile Signatures from Skin, Naevi and Melanoma: A Novel Approach to Detect a Pathological Process | [21] |
| Acharjee et al. | 2021 | Am J Transl Res. | Multi-omics-based identification of atopic dermatitis target genes and their potential associations with metabolites and miRNAs. | [22] |
| Afghani et al. | 2021 | Metabolites | Enhanced Access to the Health-Related Skin Metabolome by Fast, Reproducible and Non-Invasive WET PREP Sampling | [18] |
| Al-Mubarak et al. | 2011 | PLoS Negl Trop Dis | Serum Metabolomics Reveals Higher Levels of Polyunsaturated Fatty Acids in Lepromatous Leprosy: Potential Markers for Susceptibility and Pathogenesis | [23] |
| Alkhalil et al. | 2020 | J Burn Care Res | Cutaneous Thermal Injury Modulates Blood and Skin Metabolomes Differently in a Murine Model | [24] |
| Armstrong et al. | 2014 | F1000Res | Metabolomics in psoriatic disease: pilot study reveals metabolite differences in psoriasis and psoriatic arthritis | [25] |
| Ashrafi et al. | 2020 | PLoS ONE | A microbiome and metabolomic signature of phases of cutaneous healing identified by profiling sequential acute wounds of human skin: An exploratory study. | [10] |
| Bai et al. | 2019 | EBioMedicine | Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes. | [26] |
| Bengtsson et al. | 2016 | PLoS ONE | Metabolic Profiling of Systemic Lupus Erythematosus and Comparison with Primary Sjögren’s Syndrome and Systemic Sclerosis | [27] |
| Cappellozza et al. | 2021 | Microsc Microanal | Integrated Microscopy and Metabolomics to Test an Innovative Fluid Dynamic System for Skin Explants In Vitro | [28] |
| Carrola et al. | 2016 | Nanotoxicology | Metabolomics of silver nanoparticles toxicity in HaCaT cells: Structure-activity relationships and role of ionic silver and oxidative stress | [29] |
| Chao et al. | 2017 | Phytomedicine | Melaleuca quinquenervia essential oil inhibits α-melanocyte-stimulating hormone-induced melanin production and oxidative stress in B16 melanoma cells. | [30] |
| Chen et al. | 2021 | Theranostics | Metabolomic profiling reveals amino acid and carnitine alterations as metabolic signatures in psoriasis | [31] |
| Chen et al. | 2021 | J Invest Dermatol | Measurement of Melanin Metabolism in Live Cells by [U-13 C]-L-Tyrosine Fate Tracing Using Liquid Chromatography-Mass Spectrometry. | [32] |
| Cheng et al. | 2020 | Biomed Chromatogrs | Spleen and thymus metabolomics strategy to explore the immunoregulatory mechanism of total withanolides from the leaves of Datura metel L. on imiquimod induced psoriatic skin dermatitis in mice | [33] |
| Cheng et al. | 2020 | J Pharm Biomed Anal | Integrated serum metabolomics and network pharmacology approach to reveal the potential mechanisms of withanolides from the leaves of Datura metel L. on psoriasis. | [34] |
| Dutkiewicz et al. | 2016 | Clin Chem | Hydrogel Micropatch and Mass Spectrometry–Assisted Screening for Psoriasis-Related Skin Metabolites | [35] |
| Elbayed et al. | 2013 | Chem Res Toxicol | HR-MAS NMR Spectroscopy of Reconstructed Human Epidermis: Potential for the in Situ Investigation of the Chemical Interactions between Skin Allergens and Nucleophilic Amino Acids. | [36] |
| Emmert et al. | 2020 | Exp Dermatol | Stratum corneum lipidomics analysis reveals altered ceramide profile in atopic dermatitis patients across body sites with correlated changes in skin microbiome. | [37] |
| Fedele et al. | 2013 | Biomed Pharmacother | Prognostic relationship of metabolic profile obtained of melanoma B16F10. | [38] |
| Fitzgerald et al. | 2020 | J Proteome Res | Host Metabolic Response in Early Lyme Disease | [39] |
| Frontiñán-Rubio et al. | 2018 | Nanoscale | Differential effects of graphene materials on the metabolism and function of human skin cells. | [40] |
| Fukumoto et al. | 2017 | J Dermatol | Novel serum metabolomics-based approach by gas chromatography/triple quadrupole mass spectrometry for detection of human skin cancers: candidate biomarkers. | [41] |
| Gao et al. | 2012 | Anal Bioanal Chem | A reversed-phase capillary ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) method for comprehensive top-down/bottom-up lipid profiling | [17] |
| Harker et al. | 2014 | J Dermatol Sci | Functional characterisation of a SNP in the ABCC11 allele—Effects on axillary skin metabolism, odour generation and associated behaviours | [42] |
| Hashimoto et al. | 2019 | Pharm Res | Metabolome Analysis Reveals Dermal Histamine Accumulation in Murine Dermatitis Provoked by Genetic Deletion of P-Glycoprotein and Breast Cancer Resistance Protein | [43] |
| Hellmann et al. | 2018 | J Invest Dermatol | Biosynthesis of D-series resolvins in skin provides insights into their role in tissue repair | [44] |
| Hollywood et al. | 2015 | Mol Biosyst | Exploring the mode of action of dithranol therapy for psoriasis: a metabolomic analysis using HaCaT cells. | [45] |
| Hooton, Li. | 2017 | Anal Chem | Nonocclusive Sweat Collection Combined with Chemical Isotope Labeling LC-MS for Human Sweat Metabolomics and Mapping the Sweat Metabolomes at Different Skin Locations. | [46] |
| Hosseini et al. | 2018 | Cell Rep | Energy Metabolism Rewiring Precedes UVB-Induced Primary Skin Tumor Formation | [47] |
| Huang et al. | 2014 | J Proteome Res | Serum Metabolomics Study and Eicosanoid Analysis of Childhood Atopic Dermatitis Based on Liquid Chromatography-Mass Spectrometry | [48] |
| Ilves et al. | 2021 | Acta Derm Venereol | Metabolomic Analysis of Skin Biopsies from Patients with Atopic Dermatitis Reveals Hallmarks of Inflammation, Disrupted Barrier Function and Oxidative Stress. | [49] |
| Jacob et al. | 2019 | Metabolites | Metabolomics Distinguishes DOCK8 Deficiency from Atopic Dermatitis: Towards a Biomarker Discovery | [50] |
| Jacques et al. | 2021 | Arch Toxic | Safety assessment of cosmetics by read across applied to metabolomics data of in vitro skin and liver models | [51] |
| Jansen et al. | 2013 | PNAS | ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release | [52] |
| Jiang, Kang, Yu. | 2017 | J Chromatogr B Analyt Technol Biomed | Cross-platform metabolomics investigating the intracellular metabolic alterations of HaCaT cells exposed to phenanthrene | [53] |
| Jung et al. | 2019 | Sci Rep | Seven-day Green tea Supplementation Revamps Gut Microbiome and caecum/Skin Metabolome in Mice from Stress | [54] |
| Kaiser et al. | 2021 | JMIR Res Proto | Multiscale Biology of Cardiovascular Risk in Psoriasis: Protocol for a Case-Control Study | [55] |
| Kamleh et al. | 2015 | J. Proteome Res. | LC-MS Metabolomics of Psoriasis Patients Reveals Disease Severity Dependent Increases in Circulating Amino Acids That Are Ameliorated by Anti-TNFα Treatment. | [56] |
| Kang et al. | 2017 | Br J Dermatol. | Exploration of candidate biomarkers for human psoriasis based on gas chromatography-mass spectrometry serum metabolomics. | [57] |
| Khandelwal et al. | 2014 | J Lipid Res | 1H NMR-based lipidomics of rodent fur: species-specific lipid profiles and SCD1 inhibitor-related dermal toxicity. | [58] |
| Khosravi et al. | 2019 | Mol Med. | Active repurposing of drug candidates for melanoma based on GWAS, PheWAS and a wide range of omics data. | [59] |
| Kim et al. | 1989 | J Invest Dermatol | 1H NMR Spectroscopy: An Approach to Evaluation of Diseased Skin In Vivo. | [60] |
| Kishikawaa et al. | 2021 | Journal of Dermatological Science | Large-scale plasma-metabolome analysis identifies potential biomarkers of psoriasis and its clinical subtypes | [61] |
| Kosmopoulou et al. | 2020 | Int. J. Mol. Sci. | Human Melanoma-Cell Metabolic Profiling: Identification of Novel Biomarkers Indicating Metastasis. | [62] |
| Kuehne et al. | 2015 | Mol Cell | Acute Activation of Oxidative Pentose Phosphate Pathway as First-Line Response to Oxidative Stress in Human Skin Cells | [63] |
| Kuehne et al. | 2017 | BMC Genomics | An integrative metabolomics and transcriptomics study to identify metabolic alterations in aged skin of humans in vivo. | [64] |
| Le et al. | 2018 | J Mass Spectrom. | Accelerated, untargeted metabolomics analysis of cutaneous T-cell lymphoma reveals metabolic shifts in plasma and tumor adjacent skins of xenograft mice. | [65] |
| Lee et al. | 2021 | Scientific Reports | The potential pathways underlying the association of propyl paraben exposure with aeroallergen sensitization and EASI score using metabolomics analysis. | [13] |
| Li, Wei, Kuang. | 2021 | J Pharm Biomed Anal | UPLC-orbitrap-MS-based metabolic profiling of HaCaT cells exposed to withanolides extracted from Datura metel.L: Insights from an untargeted metabolomics. | [66] |
| Li et al. | 2021 | Front Pharmacol | Pithecellobium clypearia: Amelioration Effect on Imiquimod-Induced Psoriasis in Mice Based on a Tissue Metabonomic Analysis | [67] |
| Liang, Zhang, Cai. | 2021 | Sci Total Environ | New insights into the cellular mechanism of triclosan-induced dermal toxicity from a combined metabolomic and lipidomic approach | [68] |
| Liu et al. | 2020 | Cells | (R)-Salbutamol Improves Imiquimod-Induced Psoriasis-Like Skin Dermatitis by Regulating the Th17/Tregs Balance and Glycerophospholipid Metabolism. | [69] |
| Lutz et al. | 2007 | Wound Rep Reg | Conditions of wound healing and cutaneous growth affect metabolic performance of skin following plastic surgery | [70] |
| Malvi et al. | 2021 | Mol Metab | N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production | [71] |
| Marathe et al. | 2021 | J Invest Dermatol | Multi-omics analysis and systems biology integration identifies the roles of IL-9 in keratinocyte metabolic reprogramming. | [72] |
| Mayboroda et al. | 2016 | Int J Infect Dis | Exploratory urinary metabolomics of type 1 leprosy reactions | [73] |
| Mendez et al. | 2020 | In Vitro Cel Dev Biol Anim | Delineating cell behavior and metabolism of non-melanoma skin cancer in vitro. | [74] |
| Misra et al. | 2021 | Sci Rep | Multi-omics analysis to decipher the molecular link between chronic exposure to pollution and human skin dysfunction | [75] |
| Molins et al. | 2017 | Sci Transl Med. | Metabolic Differentiation of Early Lyme Disease from Southern Tick-Associated Rash Illness (STARI). | [76] |
| Mora-Ortiz et al. | 2019 | Metabolomics | Thanatometabolomics: introducing NMR-based metabolomics to identify metabolic biomarkers of the time of death | [77] |
| Morvan, Cachin. | 2022 | J Proteome Res | Untargeted 2D NMR Metabolomics of [13C-methyl]Methionine-Labeled Tumor Models Reveals the Non-DNA Methylome and Provides Clues to Methyl Metabolism Shift during Tumor Progression | [78] |
| Mun et al. | 2016 | PLoS ONE | Discrimination of Basal Cell Carcinoma from Normal Skin Tissue Using High-Resolution Magic Angle Spinning 1H NMR Spectroscopy | [79] |
| Niang et al. | 2015 | Sci Rep | Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease | [80] |
| Niedzwiecki et al. | 2018 | Anal Chem | Human Suction Blister Fluid Composition Determined Using HighResolution Metabolomics | [81] |
| Ottas et al. | 2017 | Arch Dermatol Res | The metabolic analysis of psoriasis identifies the associated metabolites while providing computational models for the monitoring of the disease. | [82] |
| Palacios-Ferrer et al. | 2021 | Mol Oncol | Metabolomic profile of cancer stem cell-derived exosomes from patients with malignant melanoma | [83] |
| Protsyuk et al. | 2018 | Nat Protoc | 3D molecular cartography using LC–MS facilitated by Optimus and ‘ili software. | [16] |
| Rasmussen et al. | 2016 | J Proteome Res | Untargeted metabolomics analysis of ABCC6-deficient mice discloses an altered metabolic liver profile | [84] |
| Righi et al. | 2021 | Cancers | Metabolomic Analysis of Actinic Keratosis and SCC Suggests a Grade-Independent Model of Squamous Cancerization | [85] |
| Righi et al. | 2019 | Sci Rep | Field cancerization therapy with ingenol mebutate contributes to restoring skin-metabolism to normal-state in patients with actinic keratosis: a metabolomic analysis | [14] |
| Sahoo et al. | 2017 | J Invest Dermatol | MicroRNA-211 Regulates Oxidative Phosphorylation and Energy Metabolism in Human Vitiligo. | [86] |
| Santana-Filho et al. | 2017 | Sci Rep | NMR metabolic fingerprints of murine melanocyte and melanoma cell lines: application to biomarker discovery | [87] |
| Sarkar et al. | 2017 | J Invest Dermatol | Endogenous glucocorti-coid deficiency in psoriasis promotes inflammation and ab-normal differentiation | [88] |
| Schilf et al. | 2021 | Int J. Mol Sci | A Mitochondrial Polymorphism Alters Immune Cell Metabolism and Protects Mice from Skin Inflammation | [89] |
| Seo et al. | 2020 | Molecules | Metabolomics Reveals the Alteration of Metabolic Pathway by Alpha-Melanocyte-Stimulating Hormone in B16F10 Melanoma Cells. | [90] |
| Sitter et al. | 2013 | BMC Dermatol | Metabolic changes in psoriatic skin under topical corticosteroid treatment | [91] |
| Sood et al. | 2017 | Wound Repair Regen | Targeted metabolic profiling of wounds in diabetic and nondiabetic mice. | [92] |
| Sreedhar et al. | 2019 | Proteomics | UCP2 overexpression redirects glucose into anabolic metabolic pathways. | [93] |
| Tarentini et al. | 2021 | Sci Rep | Integrated metabolomic analysis and cytokine profiling define clusters of immuno-metabolic correlation in new-onset psoriasis | [94] |
| Taylor et al. | 2020 | PLoS ONE | Metabolomics of primary cutaneous melanoma and matched adjacent extratumoral microenvironment. | [95] |
| Tilton et al. | 2015 | Toxicol Appl Pharmacol | Data integration reveals key homeostatic mechanisms following low dose radiation exposure | [96] |
| Wang et al. | 2018 | AMIA Annu Symp Proc | Combining mechanism-based prediction with patient-based profiling for psoriasis metabolomics biomarker discovery. | [97] |
| Wei et al. | 2019 | BMJ Open. | The association of tryptophan and phenylalanine are associated with arsenic-induced skin lesions in a Chinese population chronically exposed to arsenic via drinking water: a case–control study. | [98] |
| Wild et al. | 2021 | Acta Physiol (Oxf) | Aestivation motifs explain hypertension and muscle mass loss in mice with psoriatic skin barrier defect. | [99] |
| Wilkins et al. | 2021 | Metabolomics | A comprehensive protocol for multiplatform metabolomics analysis in patient-derived skin fibroblasts. | [15] |
| Wooding et al. | 2020 | Anal Bioanal Chem | Chemical profiling of the human skin surface for malaria vector control via a non-invasive sorptive sampler with GC×GC-TOFMS | [100] |
| Yang et al. | 2021 | Sci Rep | Metabolomics study of fbroblasts damaged by UVB and BaP | [101] |
| Zeng et al. | 2017 | Gigascience | Lipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis. | [102] |
| Zhang et al. | 2020 | J Ethnopharmacol | NMR-based metabolomic analysis for the effects of Huiyang Shengji extract on rat diabetic skin ulcers. | [103] |
| Zhang et al. | 2019 | Metabolomics | Metabolomic profiling for identification of potential biomarker in patients with dermatomyositis | [104] |
| Zhou et al. | 2017 | Oncotarget | Integration of microRNAome, proteomics and metabolomics to analyze arsenic-induced malignant cell transformation | [105] |
| Zhu et al. | 2021 | Front Pharmacol | Integrated Proteomics and Metabolomics Link Acne to the Action Mechanisms of Cryptotanshinone Intervention | [106] |
| Zhu et al. | 2020 | Molecules | The Synthetic Flavonoid Derivative GL-V9 Induces Apoptosis and Autophagy in Cutaneous Squamous Cell Carcinoma via Suppressing AKT-Regulated HK2 and mTOR Signals | [107] |
| Zinkevičienė et al. | 2016 | Int Arch Allergy Immunol | Activation of Tryptophan and Phenylalanine Catabolism in the Remission Phase of Allergic Contact Dermatitis: A Pilot Study | [108] |