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. 2022 Aug 1;23(15):8528. doi: 10.3390/ijms23158528

Figure 2.

Figure 2

Loss of heterozygosity in mitosis. (A): Mitosis without recombination: there is no LOH. (B): Mitosis with one crossing-over event: daughter cells produced by x segregation have LOH. (C): Values of LOH and fitness over 200 generations with one lethal equivalent (λ = 1) and one (r = 1) or three (r = 3) crossing-over events with random segregation (probability of x segregation x = 0.5). (D): LOH and fitness at equilibrium as a function of λ (the number of lethal equivalents) for different values of r (number of crossing-over events per replication) with x segregation occurring with the same probability (x = 0.5) as z segregation. (E): LOH and fitness at equilibrium as a function of λ for different values of r with x segregation only (x = 1). (F): LOH and fitness at equilibrium as a function of λ for different values of x with one crossing-over event (r = 1).