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Loss of heterozygosity in mitosis with tetraploidy. (A): LOH and fitness at equilibrium. (B): Differences in LOH and fitness between tetraploid and diploid mitosis. LOH and fitness (for A) or their difference (for B) are plotted as a function of λ (the number of lethal equivalents) for different values of r (number of crossing-over event per replication) with x segregation occurring with the same probability (x = 0.5) as z segregation.
