Figure 4.

Loss of complementation in endomitosis. (A): Endomitosis with pairing of sister chromosomes: there is no LOH, with or without (shown here) recombination. (B): Endomitosis with pairing of non-sister chromosomes and no recombination: total LOH occurs in half of the daughter cells. (C): Endomitosis with pairing of non-sister chromosomes and recombination (one crossing-over event): partial LOH occurs in some of the daughter cells. (D): LOH and fitness at equilibrium for endomitosis. (E): Differences between endomitosis and diploid mitosis. LOH and fitness (for D) or their difference (for E) are plotted as a function of λ (the number of lethal equivalents) for different values of r (number of crossing-over events) with s = 0.5 (random pairing of chromosomes) and for different values of s (the probability of sister chromosome pairing) with r = 1 (one crossing-over event).