Figure 2.

TB immunometabolism in the granuloma. Granuloma develops as TB disease progresses, which contains Mtb but also helps Mtb to persist in the host. The core of granuloma is highly hypoxic and inflammatory, mainly maintained by glycolysis, to kill Mtb but causes damage to host tissues. Moving to the granuloma periphery, the environment becomes less inflammatory with increased tissue repair functions but favourable to Mtb survival. Adapted from “Granuloma”, by BioRender.com (2022). Retrieved from https://app.biorender.com/biorender-templates, accessed on 19 June 2022.