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. 2022 Aug 2;23(15):8578. doi: 10.3390/ijms23158578

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Association of miRNA profile in patients with immune-mediated inflammatory diseases (IMID) with serum levels of VIP. (A) Graphical representation of cluster analysis based on miR215p, miR27a-5p, and miR100-5p expression in 45 IMID patients. K-means clustering based on Euclidean distance and principal component analysis (PCA) was applied. (B) Serum VIP levels (pg/mL) of IMID patients according to their association with miRNA expression cluster. Statistical significance was calculated using the variable of serum VIP levels normalized by inverse square root and applying Student’s t-test. Data are presented as the interquartile range (p75: upper edge of the box, p25: bottom edge of the box, and p50: midline) and p90 and p10 (lines below and above the box) of the serum VIP levels. Significance threshold was set at p < 0.05.