Table 3.
An overview of a selection of the latest clinical trials of µg-induced BL and countermeasures.
| Title and Identification Number | Subjects | Design | Outcome | Status/Conclusion |
|---|---|---|---|---|
| The Effects of Whole Body Unloading on Physiological Function (NCT03195348) | 12 | IV SG | Investigate the effects of hyper-buoyancy flotation in 7 days on skeletal muscles and bone mineral density. | Completed. No results posted yet. |
| A New Nutritional Countermeasure to Prevent the Deconditioning Induced by 60 Days of Antiorthostatic Bed Rest (NCT03594799) | 20 | IV RP Investigator masking |
Investigate if XXS-2A-BR2 prevents or reduces the harmful effects caused by physical inactivity through 60 days of bed rest. Secondary outcome is the change in urinary C-telopeptide of type I collagen. | Completed. No effect on urinary C-telopeptide of type I collagen, serum β-C-telopeptide of type I collagen, NTX, alkaline phosphatase, P1NP, or osteocalcin. |
| Thigh Cuffs to Prevent the Deconditioning Induced by 5 Days of Dry Immersion (NCT03915457) | 20 | IV RP No masking |
Investigate if thigh cuffs prevent or reduce the deconditioning caused by dry immersion. The outcome is the change in the balance of bone remodeling markers. | Completed. No results posted yet. |
| Planetary Habitat Simulation: Bone Metabolism Studies (NCT02637921) | 14 | IV RC Open-label masking |
Investigate the effect of hypoxia and bed rest on bone metabolism. Outcomes include the change in markers of bone cell activity. | Completed. Serum calcium and NTX increased, while P1NP decreased. No difference between normoxia or hypoxia. |
| Understanding the Negative Effects of Bed Rest and Using Exercise as Countermeasure (NCT04964999) | 24 | IV RP Open-label masking |
Investigate if exercise counteracts the negative effects caused by 2 week head-down tilt bed rest on bone markers among others. | Recruiting. |
| Integrative Study of Physiological Changes Induced by a 5-Day Dry Immersion on 20 Healthy Female Volunteers (NCT05043974) | 20 | IV SG Open-label masking |
Investigate the changes caused by dry immersion for 5 days in female physiology. The outcome is the change in bone metabolism and bone mineral density. | Recruiting. |
Abbreviations: NCT: national clinical trial, IV: interventional, SG: single-group assignment, RP: randomized parallel assignment, NTX: urinary N-telopeptide of type I collagen, P1NP: N-terminal propeptide of type 1 procollagen, RC: randomized crossover assignment.