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Reagents and conditions: (a) 4-amino-1-benzylpiperidine, EtOH, 80 °C, 2 h, quantitative yield; (b) triphosgene, dry DCM, 50 °C, 0.5 h then TEA, 50 °C, 12 h, 60%; (c) H2, Pd/C 10%, MeOH, 25 °C, 2 h, quantitative yield; (d) 1H-1,2,4-triazole, phosgene (20% in toluene), DMAP, dry DCM, 25 °C, 12 h, 63%.
