Figure 7.

The role of PEBP4 in regulation of metastasis of HCC. (A–C) MHCC97H/sh-NC or MHCC97H/sh-PEBP4 cells were injected into tail veins of nude mice (n = 5/group) and 10 weeks later, lungs were dissected and photographed. The representative images of lung appearance were shown (A). The metastatic nodules in the lung were counted and plotted (B). Representative hematoxylin and eosin (H&E) stained images of the lung were shown (magnification: ×40, ×100, ×400) (C). (D–F). MHCC97L/pCMV6-PEBP4 and MHCC97L/pCMV6-NC cells were injected, and lung metastasis was assessed similarly to (A–C). Arrows point to metastatic nodules. Data were presented as mean ± SEM (n = 5), ** p < 0.01.