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Exogenous ANP treatment in diet-induced obesity ameliorates not only systemic insulin resistance but also myocardial insulin resistance and protects against ischemia-reperfusion injury, which is associated with significant modifications of mitochondrial ultrastructure. CSCI, continuous subcutaneous infusion; IRI, ischemia-reperfusion injury; LD, lipid droplet; NAFLD, non-alcoholic fatty liver disease.
