Table 1.

Baseline cardiac function of ex vivo perfused hearts with or without ANP treatment. ‡ p < 0.05 and ‡‡ p < 0.01 versus the NFD group. HFD, high-fat diet; HR, heart rate; LVDP, left ventricular-developed pressure; LVEDP, left ventricular end-diastolic pressure; LVSP, left ventricular systolic pressure; NFD, normal-fat diet; RPP, rate pressure product.

	NFD	NFD+ANP	HFD	HFD+ANP
	(n = 14)	(n = 14)	(n = 13)	(n = 13)
LVSP, mmHg	92.5 ± 3.7	91.4 ± 3.0	121.0 ± 3.7 ‡‡	111.4 ± 3.3 ‡‡
LVEDP, mmHg	8.9 ± 0.7	7.8 ± 0.7	9.6 ± 0.7	9.8 ± 0.7
LVDP, mmHg	83.6 ± 3.5	83.5 ± 2.9	105.8 ± 5.2 ‡‡	101.6 ± 3.5 ‡‡
+dp/dt, mmHg/s	2360 ± 169	2338 ± 125	3214 ± 256 ‡‡	2746 ± 136
−dp/dt, mmHg/s	−2227 ± 192	−2204 ± 153	−2980 ± 285 ‡	−2468 ± 126
HR, bpm	268 ± 17	280 ± 19	302 ± 16	248 ± 18
RPP, mmHg·bpm	25,314 ± 2422	25,981 ± 2454	35,733 ± 2564 ‡	27,690 ± 2200
Coronary flow, mL/min	3.06 ± 0.28	3.30 ± 0.35	4.17 ± 0.31 ‡	3.08 ± 0.31