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. 2022 Aug 1;23(15):8543. doi: 10.3390/ijms23158543

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of phenylethylamine derivatives on resting [³H]dopamine release from rat striatum. For the experimental procedure, see Figure 2B. (A) The trace amine phenylethylamine (PEA) and the releaser (±)methamphetamine (methamph) induced non-vesicular [³H]dopamine release, whereas N,α-diethylphenylethylamine (DEA) and the enhancer compound (−)PPAP were without effect on [³H]dopamine release. Drugs were added to rat striatal slices from fraction 10 in a concentration of 10 µmol/L, ((±)methamphetamine 6.75 µmol/L) and maintained through the experiment, mean ± S.E.M., n = 4. (B) The enhancer compounds (−)PPAP, (−)IPAP, and (−)BPAP were without effect on non-vesicular [³H]dopamine release. Drugs were added to rat striatal slices from fraction 10 in a concentration of 10 µmol/L and maintained through the experiment, mean ± S.E.M., n = 4. The control for Figure 3A,B is shown in Figure 2B.