Figure 7.

Effect of nomifensine on [³H]dopamine release from rat striatum. For the experimental procedure, see Figure 2A. (A) Filled circles indicate [³H]dopamine release in the presence and absence of nomifensine. Nomifensine was added to striatal slices from fraction 8 in a concentration of 10 µmol/L and maintained throughout the experiment. The B2/B1 ratio for resting release was 0.78 ± 0.02 in control and it was 0.80 ± 0.07 in the presence of nomifensine, not differing significantly. The S2/S1 ratio for electrical stimulation-induced release was 0.89 ± 0.05 in control and nomifensine increased this release to 1.27 ± 0.16 (p < 0.05). Student t-statistics for two-means, mean ± S.E.M., n = 8-4. (B) Nomifensine concentration dependently increased the electrically induced (vesicular) but not the resting (non-vesicular) [³H]dopamine release in striatal slices. One-way ANOVA followed by the Dunnett’s test, F(2,16) = 0.212, p = 0.812 for resting release and F(2,16) = 4.993, p = 0.02, * p < 0.05 for electrically stimulated release, mean ± S.E.M., n = 4-8.