Figure 10.

Effect of EPPTB on [³H]dopamine release from rat striatum. For the experimental procedure, see Figure 2A. (A) Filled circles indicate [³H]dopamine release in the presence and absence of EPPTB. EPPTB was added to striatal slices from fraction 8 in a concentration of 1 µmol/L and maintained through the experiment. The B2/B1 ratio for resting release was 0.85 ± 0.05 in control and it was 0.88 ± 0.07 in the presence of EPPTB, not differing significantly. The S2/S1 ratio for electrical stimulation-induced release was 0.94 ± 0.02 in control and it was 0.95 ± 0.03 in the presence of EPPTB. This difference was not significant: Student t-statistics for two-means, p > 0.05, mean ± S.E.M., n = 3-3. (B) Concentration-dependent effect of EPPTB on electrical stimulation-induced [³H]dopamine release in rat striatum. EPPTB was added to striatal slices from fraction 8 in concentrations varied from 0.01 to 1 µmol/L and maintained through the experiment. One-way ANOVA followed by the Dunnett’s test, F(3,13) = 1.757, p = 0.204, mean ± S.E.M., n = 3-8.