Figure 12.
EPPTB reversed the (−)BPAP-induced [3H]dopamine release in rat striatum. For the experimental procedure, see Figure 2A. (−)BPAP was added to striatal slices from fraction 8 in a concentration of either 10−12 (A) or 10−11 mol/L (B) in the presence and absence of EPPTB. When used, EPPTB was added to striatal slices from fraction 1 in a concentration of either 0.01 or 0.1 µmol/L and drugs were maintained through the experiment. (A) One-way ANOVA followed by the Dunnett’s test, F(3,28) = 12.310, p < 0.001, # p < 0.01; Student t-statistics for two-means, control vs. (−)BPAP effect p < 0.05, (−)BPAP vs. (−)BPAP, and EPPTB (0.01 and 0.1 µmol/L) effects * p < 0.01, mean ± S.E.M., n = 7-10. (B) One-way ANOVA followed by the Dunnett’s test, F(3,23) = 3.890, p = 0.022, Student t-statistics for two-means, control vs. (−)BPAP effect # p < 0.01, (−)BPAP vs. (−)BPAP and EPPTB (0.1 µmol/L) effect * p < 0.01, mean ± S.E.M., n = 6-8.