Figure 16.
Phorbol 12-myristate 13-acetate (PMA) increased electrical stimulation-induced [3H]dopamine release from rat striatum. For the experimental procedure, see Figure 2A. PMA was added to striatal slices from fraction 8 in a concentration range varied from 0.01 to 1 µmol/L and maintained through the experiment. Resting release expressed by the B2/B1 ratio was 0.79 ± 0.03 in control and it was 0.71 ± 0.23 in the presence of 1 µmol/L PMA, not differing significantly. 1 µmol/L PMA increased the electrical stimulation-induced [3H]dopamine release, * p < 0.01. One-way ANOVA followed by the Dunnett’s test, F(3,12) = 7.196, p = 0.0051, * p < 0.01, mean ± S.E.M., n = 4.