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. 2022 Aug 1;23(15):8543. doi: 10.3390/ijms23158543

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of N-ethylmaleimide (NEM) on [³H]dopamine release from rat striatum. For the experimental procedure, see Figure 2A. (A) Filled circles indicate [³H]dopamine release in the presence and absence of NEM. NEM was added to striatal slices from fraction 8 in a concentration of 30 µmol/L and maintained through the experiment. Resting release expressed by the B2/B1 ratio was 0.93 ± 0.06 in control, and it was 1.07 ± 0.07 in the presence of NEM, not differing significantly. The electrical stimulation-induced release expressed by the S2/S1 ratio was 0.88 ± 0.06 in the control and 1.63 ± 0.23 in the presence of 30 µmol/L NEM, p = 0.009. Student t-statistics for two-means, mean ± S.E.M., n = 7-7. (B) NEM increased electrical stimulation-induced [³H]dopamine release in rat striatum. NEM was added to striatal slices from fraction 8 in a concentration range varied from 10 to 100 µmol/L and maintained through the experiment. One-way ANOVA followed by the Dunnett’s test, F(3,11) = 13.32, p = 0.006, * p < 0.05, mean ± S.E.M., n = 3-4.

Effect of N-ethylmaleimide (NEM) on [³H]dopamine release from rat striatum. For the experimental procedure, see Figure 2A. (A) Filled circles indicate [³H]dopamine release in the presence and absence of NEM. NEM was added to striatal slices from fraction 8 in a concentration of 30 µmol/L and maintained through the experiment. Resting release expressed by the B2/B1 ratio was 0.93 ± 0.06 in control, and it was 1.07 ± 0.07 in the presence of NEM, not differing significantly. The electrical stimulation-induced release expressed by the S2/S1 ratio was 0.88 ± 0.06 in the control and 1.63 ± 0.23 in the presence of 30 µmol/L NEM, p = 0.009. Student t-statistics for two-means, mean ± S.E.M., n = 7-7. (B) NEM increased electrical stimulation-induced [³H]dopamine release in rat striatum. NEM was added to striatal slices from fraction 8 in a concentration range varied from 10 to 100 µmol/L and maintained through the experiment. One-way ANOVA followed by the Dunnett’s test, F(3,11) = 13.32, p = 0.006, * p < 0.05, mean ± S.E.M., n = 3-4.