Figure 22.

EPPTB reversed the sulpiride-induced increase of [³H]dopamine release from rat striatum. For the experimental procedure, see Figure 2A. EPPTB or sulpiride was added to the slices from fraction 8 in a concentration of 0.1 or 10 µmol/L, respectively. When EPPTB and sulpiride were added in combination, EPPTB (0.1 µmol/L) was added from fraction 1 and sulpiride (10 µmol/L) was added from fraction 8 and drugs were maintained throughout the experiment. Sulpiride did not alter resting [³H]dopamine release on its own. One-way ANOVA followed by the Dunnett’s test, F(3,21) = 21.65, p = 0.001, control vs. sulpiride treated groups * p < 0.05. Student t-statistics for two means, sulpiride vs. sulpiride and EPPTB effect # p < 0.05, mean ± S.E.M., n = 4-7.