Table 5.
Comparison of patient characteristics in fetuses with and without abnormal CPR (<5th centile).
| Cerebral Dopplers in Fetuses with Normal and Abnormal CPR | Pts w/Abnormal CPR Dopplers Mean ± SEM (n = 14) |
Pts w/Normal CPR Dopplers Mean ± SEM (n = 67) |
p-Value |
|---|---|---|---|
| Mean MCA PI %ile † | 7.83% ± 2.14% | 48.14% ± 3.42% | <0.0001 *** |
| Mean ACA PI %ile † | 12.78% ± 3.29% | 39.06% ± 3.84% | 0.0011 ** |
| Mean PCA PI %ile † | 21.19% ± 6.16% | 42.05% ± 3.44% | 0.006 ** |
| # of VA PI < 5th centile § | 5/12 | 3/57 | 0.003 ** |
| Clinical Variables | |||
| GA at Analysis (wks) † | 35.68 ± 0.48 | 35.94 ± 0.18 | 0.350 |
| GA at Delivery (wks) † | 36.73 ± 0.52 | 37.69 ± 0.16 | 0.037 * |
| Birthweight (g) ‡ | 2009 ± 135.31 | 2492 ± 47.67 | 0.0001 *** |
| Cesarean Section Rate § | 4/11 (36.36%) | 10/52 (19.23%) | 0.243 |
| Fenton Birthweight (%) † | 3.93% ± 1.05% | 14.30% ± 1.71% | <0.0001 *** |
| Admission to NICU § | 5/12 (41.67%) | 12/46 (26.09%) | 0.307 |
Mann-Whitney U † or independent samples t-tests ‡ were used following a normality test. Fisher’s exact tests § were used for categorical variables. Because standard deviation equations were not published with the VA PI nomogram, we are unable to calculate PI centile for VA Dopplers. For this study, VA PI is assessed as a categorical variable that is either normal (>5th centile) or abnormal (<5th centile). Abbreviations: SEM: standard error of the mean; CPR: cerebroplacental ratio; MCA: middle cerebral artery; PI: pulsatility index; ACA: anterior cerebral artery; PCA: posterior cerebral artery; VA: vertebral artery; GA: gestational age; wks: weeks; NICU: neonatal intensive care unit. “* indicates statistical significance (* p < 0.05; ** p < 0.01; *** p < 0.001).”