Table 1.
Effect of CSO and MSO diets on hepatic fatty acid composition in LDLR-KO mice.
| Fatty Acids (%) | Control Western Diet | CSO Diet | MSO Diet |
|---|---|---|---|
| 12:0 | 0.11 ± 0.01 | 0.12 ± 0.01 | 0.09 ± 0.01 |
| 14:0 | 1.38 ± 0.05 | 1.25 ± 0.08 | 1.17 ± 0.05 |
| 16:0 | 21.82 ± 0.55 | 22.1 ± 0.22 | 21.43 ± 0.74 |
| 16:1 n-7 | 4.3 ± 0.26 | 3.64 ± 0.26 | 3.9 ± 0.26 |
| 18:0 | 5.64 ± 0.38 | 5.66 ± 0.29 | 5.05 ± 0.22 |
| 18:1 n-9 | 39.9 ± 1.02 | 32.76 ± 0.91 *** | 44.53 ± 0.48 ** #### |
| 18:1 n-7 | 2.28 ± 0.13 | 1.03 ± 0.08 **** | 1.11 ± 0.14 **** |
| 18:2 n-6 | 3.05 ± 0.1 | 13.04 ± 0.43 **** | 4.32 ± 0.5 #### |
| 18:3 n-6 | 0.04 ± 0.001 | 0.19 ± 0.01 **** | 0.06 ± 0.001 #### |
| 18:3 n-3 | 0.09 ± 0.01 | 0.61 ± 0.04 **** | 0.46 ± 0.04 *** |
| 20:0 | 0.04 ± 0.001 | 0.05 ± 0.002 | 0.04 ± 0.001 |
| 20:1 n-9 | 1.21± 0.04 | 0.47 ± 0.04 **** | 1.05 ± 0.05 #### |
| 20:2 n-6 | 0.04 ± 0.002 | 0.13 ± 0.001 **** | 0.05 ± 0.001 * #### |
| 20:3 n-6 | 1.39 ± 0.26 | 1.56 ± 0.21 | 0.06 ± 0.11 *## |
| 20:3 n-3 | N.D. | 0.01 ± 0.0001 | 0.01 ± 0.0001 |
| 20:4 n-6 | 2.74 ± 0.12 | 3.89 ± 0.19 * | 2.83 ± 0.37 # |
| 20:5 n-3 | 0.06 ± 0.001 | 0.13 ± 0.01 * | 0.27 ± 0.02 **** ## |
| 22:0 | N.D. | N.D. | 0.02 ± 0.001 |
| 22:1 n-9 | 0.1 ± 0.02 | 0.1 ± 0.06 | 0.05 ± 0.01 |
| 22:5 n-3 | 0.01 ± 0.0001 | 0.01 ± 0.001 | 0.01 ± 0.01 |
| 22:6 n-3 | 1.41 ± 0.01 | 2.29 ± 0.02 ** | 2.17 ± 0.02 ** |
| 24:0 | 0.27 ± 0.01 | 0.18 ± 0.01 ** | 0.24 ± 0.02 # |
| 24:1 n-9 | 0.1 ± 0.01 | 0.18 ± 0.09 **** | 0.18 ± 0.01 * |
| Total SFA | 29.27 ± 0.35 | 29.37 ± 0.36 | 28.05 ± 0.61 |
| Total MUFA | 48.04 ± 1.25 | 38.29 ± 1.01 **** | 50.9 ± 0.73 #### |
| Total PUFA | 8.28 ± 0.9 | 22.28 ± 0.71 **** | 10.95 ± 0.93 **** ### |
| Total n-6 PUFA | 6.74 ± 0.73 | 19.08 ± 0.57 **** | 8.06 ± 0.72 #### |
| Total n-3 PUFA | 1.69 ± 0.11 | 3.2 ± 0.17 **** | 2.88 ± 0.25 *** |
| n-6/n-3 ratio | 4.49 ± 0.23 | 6.08 ± 0.22 **** | 2.87 ± 0.21 **** #### |
Mice (n = 12/group) were fed a Western diet supplemented with 5% (w/w) CSO, MSO, or none (control) for 12 weeks. CSO: conventional soybean oil, MSO: modified soybean oil, ND: not detected, SFA: saturated fatty acids, MUFA: monounsaturated fatty acids, PUFA: polyunsaturated fatty acids. Values represent the mean ±SEM. * p < 0.05, ** p < 0.01; *** p < 0.001; **** p < 0.0001 compared with the control Western diet; # p < 0.05, ## p < 0.01, ### p < 0.001, #### p < 0.0001, compared with the CSO diet.