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Vitamin D–VDR-mediated effects on primary biliary cholangitis (PBC). Vitamin D–VDR signaling alleviates inflammation by targeting the miRNA155-SOCS1 axis in PBC. VDR/miRNA155-modulated SOCS1 expression is reduced in PBC, resulting in impaired regulation of cytokine signaling. VDR, vitamin D receptor; VDRE, vitamin D response element; miR155, microRNA 155; SOCS1, suppressor of cytokine signaling 1.
