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. 2022 Jul 29;23(15):8433. doi: 10.3390/ijms23158433

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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mRNA expression of respiratory chain complex genes encoded in the mitochondrial DNA of the SAMR1 and SAMP8 hippocampi. The SAMR1 and SAMP8 mice were dissected at 13 months of age and hippocampal mRNA was subjected to RT-qPCR. The mRNA expression of the control-treated SAMR1 mice was set to 1 and the relative mitochondrial mRNA expression of (A) mtNd1 (complex I), (B) mtCytb (complex III), (C) mtCox1 (complex IV) and (D) ATPase6 (mtAtp6, complex V) was normalized to the housekeeping gene, Gapdh. Individual values of the mise are shown as open circles with means + SD of SAMR1/SGS− (n = 12), SAMR1/SGS+ (n = 12), SAMP8/SGS− (n = 8), and SAMP8/SGS+ (n = 9). The data were analyzed by ANOVA with Tukey-Kramer’s post hoc test for multiple comparisons. † p < 0.1, * p < 0.05, ** p < 0.01, N.S., not significant.