Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 8;23(15):8814. doi: 10.3390/ijms23158814

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Hypothetical mechanism of the role of 5-HT_1A/5-HT₇ receptor heterodimerization in the mechanism of depression. Under physiological conditions, the amount of 5-HT_1A/5-HT₇ heterodimers in presynaptic neurons is higher than in postsynaptic neurons; under depression, the 5-HT_1A/5-HT_1A homo- and 5-HT_1A/5-HT₇ heterodimers ratio in presynaptic neurons shifts towards 5-HT_1A/5-HT_1A homodimers which decreases the amount of 5-HT in the synaptic cleft.