Table 1.

Receptor binding affinities (mean ± SEM) at recombinant rat iGluRs.

cmpd	R	Ki (µM)
		GluK1	GluK2	GluK3	GluK5	GluA2
DNQX 1		0.65 ± 0.03	2.1 ± 0.3	0.36 ± 0.03	7.1 ± 0.9	0.25 ± 0.01
NBQX		2.6 ± 0.1	5.4 ± 1.2	3.4 ± 0.6	152 ± 23	0.077 ± 0.010
1 2	Ph	>100	≈100	2.9 ± 0.3	>100	24 ± 6
5	3-Me-Ph	≈100	≈100	1.4 ± 0.4	>100	>100
6	4-Me-Ph	≥100	nd	6.1 ± 0.8	nd	nd
7	4-Et-Ph	>100	>100	20 ± 1	>100	>100
8	4-nPr-Ph	>100	>100	50 ± 12	>100	>100
9	4-iPr-Ph	>100	>100	38 ± 10	>100	>100
10	4-Cl-Ph	>100	>100	3.5 ± 0.7	>100	>100
11	4-CF3-Ph	≈100	>100	>100	>100	>100
12	4-MeO-Ph	>100	>100	8.3 ± 0.4	>100	>100
13	4-PhO-Ph	≥100	nd	7.9 ± 0.7	nd	nd
14	3-COOH-Ph	>100	>100	28 ± 2	>100	>100
15	4-COOH-Ph	>100	>100	31 ± 4	>100	>100
16	4-NH2SO2-Ph	>100	>100	≈100	>100	>100
17	4-FSO2-Ph	1.1 ± 0.4	>100	8.1 ± 0.4	>100	≈100
18	2-OH-Ph	>100	nd	14 ± 2	nd	nd
19	3-OH-Ph	>100	>100	3.2 ± 0.6	>100	≈100
20	4-OHCH2-Ph	≈100	>100	5.8 ± 1.5	>100	>100
21	2-NH2-Ph	14 ± 2	nd	1.0 ± 0.1	nd	nd
22	3-NH2-Ph	>100	nd	≈100	nd	nd
23	4-NH2-Ph	>100	>100	1.4 ± 0.2	>100	>100
24	4-N(CH3)2-Ph	39 ± 4	nd	24 ± 4	nd	nd
25	pyridin-4-yl	>100	>100	25 ± 6	>100	>100
26	6-hydroxypyridin-3-yl	>100	>100	11 ± 1	>100	>100
27	pyrimidin-5-yl	11 ± 2	12 ± 2	0.28 ± 0.02	>100	>100
28		≈100	>100	0.25 ± 0.01	>100	>100
29		0.15 ± 0.05	0.091 ± 0.015	0.13 ± 0.03	3.8 ± 0.1	0.23 ± 0.02

¹ Data from the reference [34]; ² Data from the reference [33]; nd—not determined.