Table 1.

Mechanisms involved in the generation of TCR diversity.

Sources of α/β TCR Diversity
Recombination of the T-cell α-genes on chromosome 14 and T-cell β-genes on chromosome 7 by RAG1/2 enzymes.	Total α-genes combination: 2392 Total β-genes combination: 1248 Total αβ-genes combination: 2,985,216 [6].
Theoretical diversity by pairing of different in-frame α- and β-chains plus junctional diversity by terminal deoxynucleotidyl transferase activity [6].	1015–1061 [14]
Experimental diversity evaluation by deep sequencing.	104–106, based on the amount of the sample.