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. 2022 Jul 28;11(15):4390. doi: 10.3390/jcm11154390

Table 2.

Summary of the demographics and clinical data for patients with solitary plasmacytoma of the larynx identified in the literature review.

No. Author (Year) Age (y) Sex Localisation Symptoms Surgery RTX Dose (cGy) CTH Relapse in the Larynx Progression to Systemic PCM Death PFS (mo) OS (mo) Ref.
1 Lu and Zhang (2020) 57 F 1 1 1 5000 0 0 0 0 8 8 [9]
2 Tanrivermis Sayit et al. (2020) 74 F 4 1, 7 0 Y 1 0 0 0 3 3 [10]
3 Ong et al. (2020) 55 M 1 NA NA NA NA NA NA NA NA NA [11]
4 Brandt et al. (2020) 54 F 1 1, 2 0 5000 0 0 0 0 18 18 [4]
5 Ge et al. (2018) 46 M 1 3, 6 0 5500 1 0 0 0 60 60 [3]
6 Krebs et al. (2017) 77 M 3 4, 5 0 4600 0 0 0 0 26 26 [12]
7 Wang et al. (2015) 43 M 6 1, 2, 4 1 N 0 1 1 0 12 60 [13]
8 Haser et al. (2015) 72 M 5 1, 4, 8 0 Y 0 0 0 0 12 12 [14]
9 Pino et al. (2015) 65 M 1 1, 2, 7 1 4600 0 0 0 0 54 54 [15]
10 Xing et al. (2015) 47 F 4 1 1 5000 0 0 0 0 18 18 [16]
11 Abrari et al. (2014) 56 M 2 4,10 0 Y 0 0 0 0 NA NA [17]
12 Loyo et al. (2013) 80 F 4 1, 2, 4, 8 1 N 0 0 0 0 NA NA [18]
13 Ghatak et al. (2013) 29 F 4 1, 4, 7 0 5000 0 0 0 0 16 16 [19]
14 Ramírez-Anguiano et al. (2012) 57 M 5 2, 4, 8 0 5400 0 0 0 0 18 18 [20]
15 Pinto et al. (2012) 49 F 1 2 1 N 0 0 0 0 NA NA [21]
16 Kim et al. (2012) 58 M 1 0 1 N 0 0 0 0 24 24 [22]
17 Ravo et al. (2012) 56 M 1 1, 4, 7 1 5000 0 0 0 0 5 5 [23]
18 De Zoysa et al. (2012) 62 F 2 2 0 Y 0 0 0 0 2 2 [24]
19 Pichi et al. (2011) 73 M 5 1, 4 0 4000 0 0 1 1 12 24 [25]
20 Zhang et al. (2010) 56 F 1 1, 2 1 N 0 0 0 0 24 24 [26]
21 González Guijarro et al. (2010) 11 M 4 2 1 4500 0 0 0 0 36 36 [27]
22 Pratibha et al. (2009) 49 M 6 1 0 4400 0 0 0 0 6 6 [28]
23 Fernández-Aceñero et al. (2009) 42 F 1 2, 7 0 Y 0 0 0 0 NA NA [29]
24 Iseri et al. (2009) 46 F 1 NA 1 Y 1 0 0 0 24 24 [30]
25 Bilić et al. (2009) 64 M 1 NA 0 N 1 NA NA NA 21 21 [31]
26 Rutherford et al. (2009) 13 F 3 NA 1 Y 0 0 0 NA 1 1 [32]
27 Vanan et al. (2009) 16 F 2 1 0 5040 0 0 0 0 12 12 [33]
28 Straetmans and Stokroos (2008) 57 M 1 NA 1 5000 0 1 0 0 2 24 [34]
29 Ozbilean Acar et al. (2008) 43 F 2 NA 1 N 0 0 0 0 24 24 [35]
30 Lewis et al. (2007) 71 M 1 1 1 Y 0 0 0 0 24 24 [36]
31 Kusunoki et al. (2007) 76 F 1 0 0 N 0 0 0 0 6 6 [37]
32 Velez et al. (2007) 64 M 4 1 1 Y 0 0 0 0 36 36 [38]
33 Nakashima et al. (2006) 39 M 1 0 1 6000 0 0 0 0 72 72 [39]
34 Nakashima et al. (2006) 59 M 1 0 1 N 0 0 0 0 180 180 [39]
35 Mackiewicz-Nartowicz et al. (2005) 79 F 2 1 1 N 0 0 0 0 NA NA [40]
36 Coskun et al. (2005) NA NA NA NA 0 Y 0 0 NA 0 NA NA [41]
37 Chao et al. (2005) 60 M 1 5, 1 0 5000 0 0 0 1 37 37 [42]
38 Sakiyama et al. (2005) 47 F 3 0 0 5000 1 1 0 0 4 88 [43]
39 Yavas et al. (2004) 43 F 2 1 0 N 0 0 0 0 NA NA [44]
40 Michalaki et al. (2003) 46 F NA NA 0 4500 0 0 0 0 49 49 [45]
41 Michalaki et al. (2003) 59 M NA NA 0 4000 0 0 0 0 67 67 [45]
42 Kamijo et al. (2002) 84 M 1 1 1 6000 0 0 0 0 24 24 [46]
43 Takeda et al. (2002) 53 F 3 NA 0 4600 0 NA NA NA NA NA [47]
44 Soni et al. (2002) 65 M 3 1, 3, 4, 7, 8 0 6000 0 0 0 0 25 25 [48]
45 Strojan et al. (2002) 65 M 1 NA 0 6000 0 0 0 1 93 93 [49]
46 Strojan et al. (2002) 72 M 2 NA 0 4600 0 0 0 1 56 56 [49]
47 Strojan et al. (2002) 50 F 1 NA 0 5000 0 0 0 0 27 27 [49]
48 Maheshwari et al. (2001) 65 M 3 3,4 0 Y 0 0 0 0 12 12 [50]
49 Nagasaka et al. (2001) 12 F 3 1,4 1 4320 0 0 0 0 48 48 [51]
50 Abe et al. (2001) 62 F NA NA 1 6500 0 NA NA NA NA NA [52]
51 Rakover et al. (2000) 38 M 2 1, 5 1 5000 0 1 0 0 5 46 [53]
52 Rosenblatt et al. (1999) 40 M 2 1 0 5000 0 0 0 0 47 47 [54]
53 Furukido et al. (1999) 78 F 2 NA 1 N 0 NA NA NA NA NA [55]
54 Yusumatsu et al. (1999) 77 M 1 NA 1 6000 0 NA NA NA NA NA [56]
55 Alexiou et al. (1999) 69 M NA NA 1 N 0 0 0 0 62 62 [57]
56 Alexiou et al. (1999) 40 M 1 NA 1 Y 0 0 0 0 20 20 [57]
57 Hotz et al. (1999) 63 M NA 4 1 4000 0 0 0 0 108 108 [58]
58 Hotz et al. (1999) 45 M NA 7 1 5500 0 NA 0 0 108 108 [58]
59 Nowak-Sadzikowska and Weiss (1998) 34 M 1 1 0 5400 0 0 0 0 120 120 [59]
60 Nowak-Sadzikowska and Weiss (1998) 50 M 2 1 0 6000 0 0 0 0 120 120 [59]
61 Nowak-Sadzikowska and Weiss (1998) 36 M 1 0 0 5400 0 0 0 0 120 120 [59]
62 Nowak-Sadzikowska and Weiss (1998) 68 F 1 1 0 5400 0 0 0 0 120 120 [59]
63 Nowak-Sadzikowska and Weiss (1998) 48 M 2 1 0 6000 0 0 0 0 120 120 [59]
64 Weiss et al. (1998) 34 M 1 1 0 5400 0 0 0 0 120 120 [60]
65 Weiss et al. (1998) 50 M 2 1 0 5400 0 0 0 0 120 120 [60]
66 Weiss et al. (1998) 36 M 1 0 0 6000 0 0 0 0 120 120 [60]
67 Weiss et al. (1998) 68 F 1 1 0 5400 0 0 0 0 120 120 [60]
68 Welsh et al. (1998) 59 M 1 3,4 0 5000 0 0 0 0 42 42 [61]
69 Bhattacharya et al. (1998) 49 F 1 7,10 0 NA NA 0 0 1 3 3 [62]
70 Sulzner et al. (1998) 49 M 1 3 0 4500 0 0 0 0 61 61 [63]
71 Susnerwala et al. (1997) 79 F NA NA 0 3500 0 0 0 0 132 132 [64]
72 Susnerwala et al. (1997) 65 M NA NA 0 4500 0 0 0 0 52 52 [64]
73 Han et al. (1996) 34 M 2 NA 1 5000 0 NA NA NA NA NA [65]
74 Rodriguez-de-Velasquez et al. (1996) 33 F 5 2 NA NA NA NA NA NA NA NA [66]
75 Abe et al. (1995) 53 F 1 NA 0 4500 0 NA NA NA NA NA [67]
76 Narożny et al. (1995) 51 M 1 1, 7, 10 0 6000 0 0 1 1 12 12 [68]
77 Narożny et al. (1995) 60 M 1 2, 4 1 5400 0 0 0 0 120 120 [68]
78 Narożny et al. (1995) 55 F 1 7 1 N 0 0 0 0 12 12 [68]
79 Narożny et al. (1995) 57 M 2 1 1 N 0 0 0 0 12 12 [68]
80 Zbären and Zimmermann (1995) 88 M 1 1, 3 1 N 0 0 0 0 72 72 [69]
81 Zbären and Zimmermann (1995) 71 M 1 1 1 N 0 0 0 0 12 12 [69]
82 Rolins et al. (1995) 43 M 1 0 0 N 0 0 0 0 36 36 [70]
83 Mochimatsu et al. (1993) 54 M 1 NA 1 5000 0 NA 1 0 144 144 [71]
84 Weissmann et al. (1993) 76 M 5 1, 3, 10 1 Y 0 0 0 0 NA NA [72]
85 Jankowska-Kuc et al. (1993) 58 M 4 1, 7 1 5950 0 0 0 0 36 36 [73]
86 Barbu et al. (1992) 69 M 1 2, 7 0 Y 0 0 0 0 36 36 [74]
87 Tateno et al. (1990) 54 M 1 NA 1 N 0 NA NA NA NA NA [75]
88 Kost (1990) 43 M 6 1 1 7000 0 0 0 NA NA 84 [76]
89 Agatsuma et al. (1989) 74 M 6 NA 1 4000 0 NA NA NA NA NA [77]
90 Gambino (1988) 47 M 1 5, 7 1 Y 0 NA NA 0 NA NA [78]
91 Gaffney et al. (1987) 80 M NA NA 0 4159 0 0 0 0 7 7 [79]
92 Gadomski et al. (1986) 54 M 2 1, 6, 7 1 N 1 0 NA 1 180 180 [80]
93 Gadomski et al. (1986) 51 M 1 1, 6, 7 0 4500 0 0 NA 0 60 60 [80]
94 Burke et al. (1986) 53 M 1 1, 3, 4 0 N 1 0 0 0 10 10 [81]
95 Gormley et al. (1985) 78 F 3 1, 4, 8 1 3250 0 0 0 0 NA NA [82]
96 Maniglia and Xue (1983) 64 F 5 1, 4 1 5000 0 0 0 1 12 12 [83]
97 Ferlito et al. (1982) 45 M 1 1 0 N 1 0 1 0 29 74 [84]
98 Bjelkenkrantz et al. (1981) NA NA 1 NA 1 5000 0 0 0 0 84 84 [85]
99 Bush et al. (1981) 52 F 1 NA 0 5500 0 0 0 1 36 36 [86]
100 Bush et al. (1981) 34 F NA NA 1 5500 0 0 0 0 42 42 [86]
101 Endo et al. (1979) 68 M 3 NA 0 N 1 NA NA NA NA NA [87]
102 Singh et al. (1979) 42 F 1 NA 1 Y 0 NA 0 NA NA 29 [88]
103 Woodruff et al. (1979) 64 F 1 NA 0 Y 0 0 0 1 72 72 [89]
104 Woodruff et al. (1979) 34 F 1 NA 0 Y 0 0 0 0 NA NA [89]
105 Cohen et al. (1978) 15 F 3 4 1 4000 0 1 0 0 3 22 [90]
106 Pahor (1978) 62 M 6 1, 4, 7 1 4500 1 1 0 0 21 31 [91]
107 Gorenstein et al. (1977) 58 M 4 1 1 Y 0 NA 0 0 36 36 [92]
108 Gorenstein et al. (1977) 63 M 4 1 1 Y 0 NA 0 0 300 300 [92]
109 Gorenstein et al. (1977) 59 M 3 4, 8 1 N 0 NA 0 1 60 60 [92]
110 Gorenstein et al. (1977) 42 M 2 1 1 N 0 NA 0 0 60 60 [92]
111 Gorenstein et al. (1977) 61 M 4 1, 7 0 Y 0 NA 0 0 72 72 [92]
112 Petrovich et al. (1977) 74 M 1 10 0 7312 0 0 0 0 24 88 [93]
113 Muller and Fischer (1976) 44 M 1 1, 8 NA NA NA NA NA NA NA NA [94]
114 Horiuchi et al. (1973) 51 F 1 NA 1 N 0 NA NA NA NA NA [95]
115 Booth et al. (1973) 54 F 4 NA 1 N 0 1 0 1 NA 264 [96]
116 Stone and Cole (1971) 67 M 1 NA 0 Y 1 0 0 0 10 10 [97]
117 Touma (1971) 65 M 4 NA 1 N 0 0 0 0 NA NA [98]
118 Kakar et al. (1970) 45 F 1 1, 4 1 N 0 0 0 0 13 13 [99]
119 Poole and Marchetta (1968) 41 M NA NA 1 Y 0 NA 0 1 NA 41 [100]
120 Nabar (1968) 60 F 1 NA 1 N 0 0 0 0 132 132 [101]
121 Nabar (1968) 55 M 1 NA 0 Y 0 0 0 1 NA NA [101]
122 Nabar (1968) 46 F 1 NA 1 N 0 0 0 0 NA NA [101]
123 Kraska (1967) 40 F 1 1, 4 0 7290 0 0 0 0 14 14 [102]
124 Studencki (1966) 54 F 4 1, 4, 10 0 5500 0 0 0 0 7 7 [103]
125 Todd (1965) 65 M 1 NA 0 2500 0 1 1 1 60 96 [104]
126 Todd (1965) 43 M 1 NA 0 4800 0 0 0 0 60 60 [104]
127 Webb et al. (1962) 55 F 4 1 1 N 0 0 0 0 132 132 [105]
128 Webb et al. (1962) 32 M 3 1 1 Y 0 0 0 0 120 120 [105]
129 Webb et al. (1962) 46 M 1 1, 9 1 Y 0 1 1 1 168 330 [105]
130 Krotz and Ritterhoff (1961) 75 M NA NA 0 Y 0 1 NA 1 NA NA [106]
131 Clark (1957) 60 F 1 1, 4, 7 1 N 0 0 0 0 1 1 [107]
132 Carson et al. (1955) 52 M 1 NA 1 Y 0 0 1 0 54 54 [108]
133 Carson et al. (1955) 73 M 1 NA 1 N 0 NA NA 1 156 156 [108]
134 Korkis (1954) 42 F 1 NA 1 N 0 0 0 0 NA NA [109]
135 Priest (1952) 50 M 4 2, 10 1 N 0 1 0 0 9 48 [110]
136 Ewing and Foote (1952) 76 M 1 1 NA Y NA 0 0 0 6 6 [111]
137 Costen (1951) 52 M 1 NA 0 Y 0 0 1 0 NA 12 [112]
138 Mattick (1950) 41 M 4 1, 3, 4, 7, 10 1 N 0 1 1 1 27 41 [113]
139 Rawson et al. (1950) 59 F 1 NA 1 Y 0 0 1 0 36 NA [114]
140 Stout and Kenney (1949) 46 M 1 4, 6 1 8400 0 1 0 0 3 171 [115]
141 Hodge and Wilson (1948) 53 M 4 1, 3, 5, 10 1 N 0 0 0 0 12 12 [116]
142 Lumb and Prossor (1948) 34 M 3 NA 0 Y 0 1 0 0 24 30 [117]
143 Lumb and Prossor (1948) 20 M 7 NA 1 Y 0 0 0 0 90 90 [117]
144 Clerf (1946) 75 M 1 NA 1 N 0 0 0 1 13 13 [118]
145 Jaeger (1942) 67 F NA NA 0 Y 0 0 0 1 6 6 [119]
146 Haven and Parkhill (1941) 62 M 1 NA 1 Y 0 0 0 0 54 54 [120]
147 Ringertz (1938) 59 M 2 1 0 Y 0 0 0 0 48 48 [121]
148 Ringertz (1938) 73 M 1 NA 1 N 0 0 0 0 12 12 [121]
149 Ringertz (1938) 57 F 1 NA 1 Y 0 0 0 1 48 48 [121]
150 Heindl (1933) NA NA NA NA 1 N 0 0 0 0 36 NA [122]
151 Blacklock and Macartney (1932) 64 M NA NA 1 N 0 0 0 0 NA 24 [123]
152 Wachter (1914) 48 F NA NA 1 N 0 0 0 0 5 142 [124]

NA—non-available data; y—years (age); mo—months; M—male; F—female; RTX—radiotherapy; CTH—chemotherapy; PCM—plasma cell myeloma; PFS—progression-free survival; OS—overall survival; Ref.—references; Localisation: 1—supraglottic, 2—glottic, 3—subglottic, 4—supraglottic + glottic, 5—glottic + subglottic, 6—supraglottic + glottic + subglottic, 7—supraglottic + subglottic; Symptoms: 0—no symptoms, 1—hoarseness, 2—dysphonia, 3—cough, 4—dyspnea, 5—globus sensation, 6—sore throat, 7—dysphagia, 8—stridor, 9—odynophagia, 10 —other; RTX: Y—non-available dose, N—no radiotherapy, NA—no information; Surgery/CTH/Local relapse/Progression to MM/Death: 1—yes, 0—no.