Figure 8.

Possible mechanism of MLKL cleavage-mediated necroptotic activation in MM cells. Cell death triggers, such as DHA, EPA and bortezomib, induce activated caspases-mediated MLKL cleavage in multiple myeloma cells, which are RIPK3-deficient cells. After cleavage, the N-terminal cleavage induce necroptosis by oligomerization and the C-terminal cleavage may be degraded by the ubiquitin–proteasome system. Small amounts of C-terminal cleavage can be phosphorylated by low abundant RIPK3 existing in MM cells and subsequently degraded. Dashed arrows, need to be further investigated.