Table 1.
Variables employed in their original form and discretized.
| Variable | Original (Non-Discretized) |
Post-Processed (Discretized) |
Description of Discretized Version |
Descriptives |
|---|---|---|---|---|
| Days since the start of UST treatment (longitudinal, not baseline) | Numeric | Numeric | - | |
| HBI at baseline, categorized | Ordinal (3) | - | [5–7] (mild), [8–16] (moderate), >16 (severe) | Distribution: Mild 50%, Moderate 45%, Severe 5% % missing values: 0% |
| Years between diagnosis and start of UST | Numeric | Dichotomous | ≤18, >18 | Median: 10.0 % missing values: 0% |
| Number of surgeries before UST treatment onset | Numeric | Ordinal (3) | 0, 1–2, ≥3 | Distribution: 0 (47%), 1–2 (43%), ≥3 (10%) |
| Number of anti-TNF episodes | Numeric | Dichotomous | ≤1, >1 | Median: 2.0 96.1% of patients ≥1 anti-TNF |
| Number of anti-integrin episodes | Numeric | Dichotomous | 0, 1 | Median: 0.0 23.7% of patients ≥1 anti-integrin |
| Age at the time of signing consent | Numeric | Dichotomous | ≤40, >40 | Median: 46.0 % missing values: 0% |
| BMI at baseline | Numeric | Ordinal (3) | <27, 27–38, >38 | Median: 23.81 % missing values: 16% |
| Sex | Dichotomous | Dichotomous | Female, Male | Distribution: Female 49%, Male 51% % missing values: 0% |
| Number of comorbidities | Numeric | Ordinal (4) | 0–1, 2–3, ≥4 | Median: 1.0 |
| Perianal disease | Categorical | Dichotomous | Never/Previous, Current | Distribution: Never/Previous 86%, Current 14% % missing values: 0% |
| CD location | Categorical | Dichotomous | Ileocolic/Ileum (L1/L3), Colon (L2) | Distribution: Ileocolic/Ileum 88%, Colon 12% % missing values: 0% |
| Patient ever had EIMs | Dichotomous | Dichotomous | Yes/No | Distribution: No 59%, Yes 41% |
| Family history of CD | Dichotomous | Dichotomous | Yes/No | Distribution: No 13%, Yes 87% % missing values: 16% |
| Upper gastrointenstinal tract (L4) involved | Dichotomous | Dichotomous | Yes/No | Distribution: No 92%, Yes 8% % missing values: 0% |
| Baseline albumin (g/L) | Numeric | Dichotomous | ≤3.8, >3.8 | Median: 4.0 % missing values: 33% |
| Baseline faecal calprotectin (mcg/g) | Numeric | Ordinal (3) | ≤80, 81–650, >650 | Median: 667.33 % missing values: 52% |
| Baseline haemoglobin (g/L) | Numeric | Dichotomous | ≤10.9, >10.9 | Median: 13.2 % missing values: 10% |
| Baseline CRP (mg/L) | Numeric | Ordinal (3) | ≤0.5, 0.6–6.1, >6.1 | Median: 7.2 % missing values: 10% |
| Steroid use at first UST dose | Dichotomous | Dichotomous | Yes/No | Distribution: No 72%, Yes 28% |
| Under Immunosuppressants at first UST dose | Dichotomous | Dichotomous | Yes/No | Distribution: No 70%, Yes 30% |
| Number of concomitant steroid courses | Numeric | Dichotomous | Yes/No | Median: 0.0 |
BMI, Body Mass Index; CD, Crohn’s Disease; CRP, C-reactive protein; EIM, extraintestinal manifestation; HBI, Harvey Bradshaw Index; TNF, Tumor Necrosis Factor; UST, ustekinumab.