TABLE 1.

Homologies of type 2 capsule genes with other bacterial genes^a

Type 2 gene	Homologous gene	Origin species or S. pneumoniae type	Proposed function of gene product	Amino acid identity and similarity (%)
cps2E	cps23fE	Type 23F	Undecaprenyl-phosphate glucose-1-phosphate transferase	95, 96
	cps14E	Type 14	Glucosyl-1-phosphate transferase	60, 79
	cps19fE	Type 19F	Uridine diphosphate glycosyltransferase	60, 78
cps2T	cps23fT	Type 23F	Rhamnosyl transferase	81, 88
cps2F	cps23fU	Type 23F	Galactosyltransferase	23, 50
	cps14J	Type 14	ss-1,4-galactosyltransferase	19, 46
	cps14I	Type 14	ss-1,3-N-acetylglucosaminyltransferase	18, 43
cps2G	Sequence encoding protein RPN00103	Type 4	Undecaprenyl-phosphate galactosephosphotransferase	35, 55
	icsA	Neisseria meningitidis	Lipopolysaccharide glycosyltransferase	19, 48
cps2H	cps23fI	Type 23F	Polysaccharide polymerase	22, 52
	cps14H	Type 14	Polysaccharide polymerase	21, 51
	cps19fI	Type 19F	Polysaccharide polymerase	20, 50
cps2I	rfaK	N. meningitidis	Alpha 1,2 N-acetylglucosamine transferase	25, 52
	icsA	N. meningitidis	Lipopolysaccharide glycosyltransferase	24, 52
cps2J	cps23fJ	Type 23F	Repeat unit transporter	36, 63
	cps14L	Type 14	Repeat unit transporter	20, 49

^aGenBank accession numbers: cps23f, AF030373; cps14, X85787; cps19f, U09239; icsA, U39810; and rfaK, U58765. Preliminary sequence data for the type 4 pneumococcal genome was obtained from The Institute for Genomic Research (15a). Annotation for the type 4 genome was obtained from reference 28a.