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. 2022 Jul 30;11(15):4461. doi: 10.3390/jcm11154461

Table 2.

Relationships between general symptoms of COVID-19 in terms of severity, duration, and the frequency and presence of oral manifestations of COVID-19.

Symptom Total
195
Severity of Specific COVID-19 Symptom Duration of Specific COVID-19 Symptom Frequency of Specific COVID-19 Symptom
Mild Moderate Severe p-Value 1–2 Days 3–4 Days 5+ Days p-Value Once Intermittent Constant p-Value
Fever 140 (72%) 34 (24%) 81 (58%) 25 (18%) 47 (35%) 46 (35%) 40 (30%) 13 (11%) 65 (53%) 45 (36%)
Oral manifestations + 43 (31%) 9 (26%) 30 (37%) 4(16%) 0.8751 15 (32%) 13 (28%) 14 (35%) 0.7971 5 (39%) 22 (34%) 11 (24%) 0.4745
Oral manifestations − 97 (69%) 25 (74%) 51 (68%) 21 (84%) 32 (68%) 33 (72%) 26 (65%) 8 (62%) 43 (66%) 34 (76%)
Headache 127 (65%) 33 (24%) 42 (33%) 52 (41%) 25 (22%) 29 (25%) 61 (53%) 10 (9%) 55 (49%) 47 (42%)
Oral manifestations + 38 (29%) 11 (33%) 12 (29%) 15 (28%) 0.8832 6 (24%) 9 (31%) 20 (33%) 0.7214 0 (0%) 22 (40%) 22 (40%) 0.0336
Oral manifestations − 89 (71%) 22 (67%) 30 (71%) 37 (72%) 19 (76%) 20 (69%) 41 (67%) 10 (100%) 33 (60%) 34 (72%)
Fatigue 126 (65%) 33 (26%) 48 (38%) 45 (36%) 19 (16%) 36 (31%) 61 (53%) 3 (3%) 37 (34%) 69 (63%)
Oral manifestations + 40 (32%) 13 (39%) 17 (35%) 10 (22%) 0.2151 2 (11%) 7 (19%) 30 (49%) 0.0007 0 (0%) 13 (35%) 22 (32%) 0.4548
Oral manifestations − 86 (68%) 20 (61%) 31 (65%) 35 (78%) 17 (89%) 29 (82%) 31 (51%) 3 (100%) 24 (65%) 47 (68%)
Cough 122 (63%) 41 (34%) 49 (40%) 32 (26%) 19 (17%) 29 (25%) 66 (58%) 5 (5%) 56 (55%) 41 (40%)
Oral manifestations + 39 (32%) 17 (42%) 16 (33%) 6 (19%) 0.1176 3 (16%) 12 (41%) 23 (35%) 0.1669 2 (40%) 21 (38%) 11 (27%) 0.5188
Oral manifestations − 83 (68%) 24 (58%) 33 (67%) 26 (81%) 16 (84%) 17 (59%) 43 (65%) 3 (60%) 35 (62%) 30 (73%)
Myalgia/arthralgia 104 (53%) 26 (25%) 37 (36%) 41 (39%) 18 (19%) 24 (26%) 52 (55%) 6 (54%) 36 (40%) 49 (6%)
Oral manifestations + 32 (31%) 11 (42%) 13 (35%) 8 (20%) 0.1111 3 (17%) 8 (33%) 20 (38%) 0.2375 0 (0%) 16 (44%) 15 (31%) 0.0736
Oral manifestations − 72 (69%) 15 (58%) 24 (65%) 33 (80%) 15 (83%) 16 (67%) 32 (62%) 6 (100%) 20 (56%) 34 (69%)
Loss of smell 102 (53%) 9 (9%) 19 (19%) 74 (72%) 5 (5%) 8 (9%) 80 (86%) 1 (1%) 4 (5%) 78 (94%)
Oral manifestations + 40 (39%) 5 (55%) 10 (53%) 25 (34%) 0.1865 1 (20%) 7 (88%) 31 (39%) 0.0122 0 (0%) 2 (50%) 33 (42%) 1.0000
Oral manifestations − 62 (61%) 4 (44%) 9 (47%) 49 (66%) 4 (80%) 1 (12%) 49 (61%) 1 (100%) 2 (50%) 45 (58%)
Sore throat 97 (50%) 33 (34%) 38 (39%) 26 (27%) 18 (20%) 39 (44%) 32 (36%) 9 (11%) 27 (33%) 47 (56%)
Oral manifestations + 34 (35%) 14 (42%) 10 (26%) 10 (38%) 0.3338 5 (28%) 15 (38%) 12 (38%) 0.7181 2 (22%) 11 (41%) 17 (36%) 0.6056
Oral manifestations − 63 (65%) 19 (58%) 28 (74%) 16 (62%) 13 (72%) 24 (62%) 20 (62%) 7 (78%) 26 (59%) 30 (64%)
Dyspnea 78 (40%) 22 (28%) 24 (31%) 32 (41%) 10 (15%) 22 (32%) 36 (53%) 8 (12%) 35 (54%) 22 (34%)
Oral manifestations + 22 (28%) 8 (36%) 7 (29%) 7(22%) 0.5048 2 (20%) 8 (36%) 11 (31%) 0.6485 2 (25%) 13 (37%) 5 (23%) 0.4818
Oral manifestations − 56 (72%) 14 (64%) 17 (71%) 25 (78%) 8 (80%) 14 (64%) 25 (69%) 6 (75%) 22 (67%) 17 (77%)
Nausea/
vomiting
41 (21%) 20 (49%) 15 (36%) 6 (15%) 11 (34%) 7 (22%) 14 (44%) 5 (13%) 22 (71%) 4 (16%)
Oral manifestations + 11 (27%) 5 (25%) 5 (33%) 1 (17%) 0.7991 1 (9%) 3 (43%) 5 (36%) 0.2099 2 (40%) 6 (27%) 1 (25%) 0.8367
Oral manifestations − 30 (73%) 15 (75%) 10 (67%) 5 (83%) 10 (91%) 4 (57%) 9 (64%) 3 (60%) 16 (73%) 3 (75%)
Diarrhea 30 (15%) 19 (63%) 8 (27%) 3 (10%) 13 (57%) 4 (17%) 6 (26%) 6 (29%) 11 (52%) 4 (19%)
Oral manifestations + 11 (37%) 7 (37%) 4 (50%) 0 (0%) 0.3861 6 (46%) 1 (25%) 2 (33%) 0.7085 4 (67%) 3 (27%) 1 (25%) 0.2329
Oral manifestations − 19 (63%) 12 (63%) 4 (50%) 3 (100%) 7 (54%) 3 (75%) 4 (67%) 2 (33%) 8 (73%) 3 (75%)

Oral manifestations +: Patient(s) developed oral manifestations of COVID-19 simultaneously with having the general symptom listed just above it. Oral manifestations −: Patient(s) did not have oral manifestations of COVID-19 simultaneously with the general symptom listed above it.