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. Author manuscript; available in PMC: 2022 Aug 11.
Published in final edited form as: Nano Res. 2019 Jul 24;12(10):2468–2476. doi: 10.1007/s12274-019-2470-0

Figure 7.

Figure 7

Molecular mechanism of DTA NP oral uptake. (a) Representative images of the entire GI tract (left) or the indicated intestinal regions isolated from mice received oral administration of IR780-loaded DTA NPs or free dye. Scale bar: 10 μm. (b) SEM images of the DTA NPs after incubation in the indicated medium for 2h. Scale bars: 500 nm. (c) Uptake of DTA NPs increased with ASBT overexpression as determined by flow cytometry. (d) In vitro transport of DTA NPs across monolayers of Caco-2 cell with and without ASBT overexpression. (e) In vitro transport of DTA NPs across monolayers of ASBT overexpressing Caco-2 cells with and without treatment of UDCA. (f) Pretreatment with 500 mg/kg UDCA inhibited the uptake of DTA NPs. *: p < 0.05; **: p < 0.005.