Skip to main content
. Author manuscript; available in PMC: 2023 Apr 29.
Published in final edited form as: Biochem Soc Trans. 2022 Apr 29;50(2):689–701. doi: 10.1042/BST20200782

Figure 2. Roles of O-glycans in Notch signaling in small intestine.

Figure 2.

Mouse NOTCH1 ECD consists of 36 EGF repeats which are modified by various O-glycans signified by the symbol for the initiating sugar. Each O-glycan is initiated at a consensus site in relevant EGF repeats by a specific glycosyltransferase as shown. The EGF repeats shown to be modified by a particular O-glycan are based on recent reviews for O-fucose and O-glucose (60) glycans, and for O-GlcNAc glycans (39). Further extension of the initial sugar by other glycosyltransferases leads to the formation of an O-glycan. The diagram summarizes the consequences of deleting different glycosyltransferase genes in the intestine (X, gene deleted; red arrow, decrease; green arrow, increase). Proposed or ongoing experiments investigating intestinal consequences in compound mutant mice are also presented.