Table 3.
Association between baseline biomarkers and SSS progression.
| Unadjusted (Model 1) | Adjusted * (Model 2) | |||
|---|---|---|---|---|
| HR (95% CI) | p-Value | HR (95% CI) | p-Value | |
| Age | 1.05 (1.01–1.09) | 0.023 | ||
| Gender | 3.39 (1.45–7.91) | 0.005 | 3.055 (1.181–7.902) | 0.021 |
| Hypertension | 1.52 (0.77–3.00) | 0.222 | ||
| Diabetes | 3.48 (1.19–10.15) | 0.023 | ||
| Hyperlipidemia | 0.96 (0.47–1.97) | 0.911 | ||
| BMI | 1.04 (0.94–1.15) | 0.486 | ||
| SBP | 1.03 (1.01–1.05) | 0.001 | ||
| DBP | 1.06 (1.02–1.09) | 0.001 | 1.051 (1.011–1.093) | 0.013 |
| Smoking | 1.50 (0.76–2.95) | 0.243 | ||
| Drinking | 1.22 (0.64–2.32) | 0.541 | ||
| Cholesterol | 1.00 (0.99–1.00) | 0.350 | ||
| Triglyceride | 1.00 (1.00–1.00) | 0.830 | ||
| Uric acid | 1.12 (0.91–1.39) | 0.281 | ||
| HDL | 0.98 (0.95–1.00) | 0.099 | ||
| LDL | 1.00 (0.99–1.01) | 0.880 | ||
| GLU | 1.01 (1.00–1.02) | 0.170 | ||
| AST | 1.00 (0.97–1.03) | 0.930 | ||
| ALT | 1.00 (0.98–1.02) | 0.930 | ||
| ALK-P | 1.01 (0.99–1.03) | 0.406 | ||
| Total bilirubin | 1.47 (0.75–2.88) | 0.261 | ||
| Direct bilirubin | 2.92 (0.22–38.99) | 0.418 | ||
| GGT | 1.00 (0.99–1.01) | 0.753 | ||
| LDH | 1.01 (1.00–1.01) | 0.184 | ||
| Albumin | 0.46 (0.12–1.73) | 0.250 | ||
| Total protein | 0.88 (0.44–1.77) | 0.728 | ||
| BUN | 1.06 (0.97–1.15) | 0.185 | ||
| Creatinine | 2.04 (0.31–13.56) | 0.460 | ||
| HsCRP | 0.62 (0.01–27.93) | 0.803 | ||
| CK | 1.00 (1.00–1.01) | 0.379 | ||
| NA | 0.95 (0.81–1.12) | 0.549 | ||
| K | 1.02 (0.40–2.57) | 0.970 | ||
| LVEF | 1.01 (0.96–1.06) | 0.666 | ||
| NFS | 1.76 (1.25–2.46) | 0.001 | 1.674 (1.169–2.397) | 0.005 |
| FIB-4 | 1.70 (0.98–2.95) | 0.059 | ||
| APRI | 4.54 (0.47–43.40) | 0.189 | ||
| Forns score | 1.91 (1.19–3.06) | 0.007 | ||
| Baseline CAC | 1.02 (1.01–1.04) | 0.003 | ||
| Baseline SSS | 1.13 (0.96–1.32) | 0.147 | ||
BMI = body mass index, HDL = high-density lipoprotein, LDL = low-density lipoprotein, AST = aspartate transaminase, ALT = alanine aminotransferase, ALK-P = alkaline phosphatase, GGT= gamma-glutamyl transferase, LDH = lactate dehydrogenase, BUN = blood urea nitrogen, eGFR = estimated glomerular filtration rate, HsCRP = high-sensitivity C-reactive protein, CK = creatine kinase, SBP = systolic blood pressure, DBP = diastolic blood pressure, NFS = nonalcoholic fatty liver disease fibrosis score, FIB-4 = fibrosis-4 index, APRI = AST to platelet ratio index, LVEF = left ventricular ejection fraction, CAC = coronary artery calcium, SSS = segment stenosis score. * Adjusted model: covariate selection for the multivariate analysis was based on p < 0.05 in univariate analysis, with a logistic regression model and a backward elimination procedure.