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. 2022 Jul 30;14(15):3145. doi: 10.3390/nu14153145

Figure 1.

Figure 1

Schematic representation of the epigenetic activity of ketone bodies and SIRT1 in response to starvation or to the ketogenic diet. Synergistically, KBs and SIRT1 target both histone and nonhistone proteins and alter cellular metabolic programs. NAD, nicotinamide adenine dinucleotide; PTMs, post-translational modifications.