Table 8.
Small molecule drugs targeting HIF to inhibit gastric cancer.
| Drugs | Target | Mechanism | References |
|---|---|---|---|
| apigenin | HIF1α | promote autophagy | [123] |
| tipifarnib | HIF1α | - | [124] |
| dextran sulfate | HIF1α | inhibit metastasis | [125] |
| schisandrin B | HIF1α | inhibit metastasis | [126] |
| Glaucocalyxin a | HIF1α | inhibit metastasis | [74] |
| Resveratrol | HIF1α | inhibit metastasis | [127] |
| Oleanolic acid | HIF1α | inhibit aerobic glycolysis | [128] |
| ginsenoside Rg3 | HIF1α | inhibit angiogenesis | [129] |
| EGCG | HIF1α | promote apoptosis | [130] |
| Wogonin | HIF1α | inhibit proliferation | [131] |
| FS-7 | HIF1α | inhibit glycolysis | [132] |
| TC24 | HIF1α | promote apoptosis | [133] |
| dextran sulphate | HIF1α | inhibit metastasis | [134] |
| Sulforaphane | HIF1α | inhibit angiogenesis | [135] |
| Quercetin | HIF1α | promote autophagy | [136] |
| Celecoxib | HIF1α | promote autophagy | [137] |