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. 2022 Aug 5;27(15):4987. doi: 10.3390/molecules27154987

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of transdermal administration of a single therapeutic dose of NanoBEO on capsaicin-induced licking/biting behavior. (A) The duration of licking/biting induced by intraplantar injection of capsaicin (1.6 μg/20 μL) is determined using the 5-min period starting immediately after injection of capsaicin. (B) NanoBEO reduces significantly capsaicin-induced licking/biting behavior after 30 min. Empty cream is used as a control and it fails to affect capsaicin-induced nociceptive response. The data presented are expressed as mean ±S.E.M. (n = 6). The value of * p < 0.05 is considered statistically significant.