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. 2022 Aug 5;27(15):4987. doi: 10.3390/molecules27154987

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of transdermal administration of a single therapeutic dose of NanoBEO on static (A,B) and dynamic (C,D) mechanical allodynia induced by partial sciatic nerve ligation (PSNL). NanoBEO reduces significantly static and dynamic mechanical allodynia occurring 30 min after the beginning of the test. Empty cream, used as a control, does not prove efficacy on both types of allodynia. The data presented are expressed as mean ±S.E.M. (n = 6). The value of * p < 0.05 is considered statistically significant.