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. 2022 Jun 24;4(1):vdac089. doi: 10.1093/noajnl/vdac089

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© The Author(s) 2022. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Clinical response to vaccination. (A) Objective response in a 57-year-old woman. New enhancement developed around the resection cavity (arrows) and in the contralateral hemisphere (circle) after radiation with concurrent temozolomide. While both regions could potentially represent treatment-related inflammatory pseudoprogression, the enhancement in the contralateral hemisphere is outside the radiation field and is therefore more likely to represent true progression. Both regions resolved with therapy. (B) New enhancement at cycle 4 in a 55-year-old man. Biopsy showed necrosis with marked inflammatory infiltrate. (C) New enhancement at cycle 7 in a 60-year-old man. Biopsy showed viable tumor without inflammatory infiltrate.